For research use only. Not for therapeutic Use.
Thiomandelic acid is a broad spectrum inhibitor of Zinc -lactamases[1].
Thiomandelic acid is found to be a reasonably potent (submicromolar) inhibitor for all of the MBLs tested, except for the subclass B2 enzyme from A. hydrophila (CphA)[1].
Thiomandelic Acid binds to both metal ions in metallo-β-lactamase and induces positive cooperativity in metal binding[2].
| Catalog Number | I037236 |
| CAS Number | 4695-09-4 |
| Synonyms | 2-phenyl-2-sulfanylacetic acid |
| Molecular Formula | C8H8O2S |
| Purity | ≥95% |
| InChI | InChI=1S/C8H8O2S/c9-8(10)7(11)6-4-2-1-3-5-6/h1-5,7,11H,(H,9,10) |
| InChIKey | QYIGFZOHYGYBLX-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)C(C(=O)O)S |
| Reference | [1]. C Mollard, et al. Thiomandelic acid, a broad spectrum inhibitor of zinc beta-lactamases: kinetic and spectroscopic studies. J Biol Chem. 2001 Nov 30;276(48):45015-23. [2]. Christian Damblon, et al. The inhibitor thiomandelic acid binds to both metal ions in metallo-beta-lactamase and induces positive cooperativity in metal binding. J Biol Chem. 2003 Aug 1;278(31):29240-51. |
