For research use only. Not for therapeutic Use.
Thiomyristoyl(CAT: I009798) is a potent and specific inhibitor of SIRT2, a member of the sirtuin family of NAD+-dependent protein deacetylases. SIRT2 is involved in various cellular processes, including cell cycle regulation, metabolism, and cellular stress response. By inhibiting SIRT2, Thiomyristoyl modulates the acetylation status of target proteins, potentially leading to alterations in cellular functions and signaling pathways.
| Catalog Number | I009798 |
| CAS Number | 1429749-41-6 |
| Synonyms | Thiomyristoyl;benzyl (S)-(1-oxo-1-(phenylamino)-6-tetradecanethioamidohexan-2-yl)carbamate |
| Molecular Formula | C34H51N3O3S |
| Purity | ≥95% |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| InChI | InChI=1S/C34H51N3O3S/c1-2-3-4-5-6-7-8-9-10-11-18-26-32(41)35-27-20-19-25-31(33(38)36-30-23-16-13-17-24-30)37-34(39)40-28-29-21-14-12-15-22-29/h12-17,21-24,31H,2-11,18-20,25-28H2,1H3,(H,35,41)(H,36,38)(H,37,39)/t31-/m0/s1 |
| InChIKey | CJQGLLUJIVNREL-HKBQPEDESA-N |
| SMILES | O=C(OCC1=CC=CC=C1)N[C@@H](CCCCNC(CCCCCCCCCCCCC)=S)C(NC2=CC=CC=C2)=O |
| Reference | 1:Org Biomol Chem. 2014 Oct 14;12(38):7498-502. doi: 10.1039/c4ob00860j. Thiomyristoyl peptides as cell-permeable Sirt6 inhibitors.He B,Hu J,Zhang X,Lin H, PMID: 25163004 PMCID: PMC4161628 DOI: 10.1039/c4ob00860j </br><span>Abstract:</span> Sirtuins regulate a variety of biological pathways and inhibitors of sirtuins have been actively pursued as tool compounds to study sirtuin biology and as potential therapeutics. Here we demonstrate that thiomyristoyl peptides are potent and cell-permeable inhibitors of Sirt6, one of the seven human sirtuins, and will serve as the starting point for the development of more specific Sirt6 inhibitors. |
