For research use only. Not for therapeutic Use.
Thioperamide (maleate) is a selective histamine H3 receptor antagonist that crosses the blood-<wbr></wbr>brain barrier. This compound binds to rat cerebral cortical cells <em>in vitro</em> with a pK<sub>i</sub> value of 8.4 and inhibits histamine binding <em>in vivo</em> with an ED<sub>50</sub> value of 1 mg/kg. At a dose of 5 mg/kg thioperamide (maleate) inhibits kindled seizures in rats by decreasing histamine and gamma-<wbr></wbr>aminobutyric acid.
| Catalog Number | M101958 |
| CAS Number | 148440-81-7 |
| Synonyms | N-cyclohexyl-4-(1H-imidazol-5-yl)-1-piperidinecarbothioamide, 2Z-butenedioate |
| Molecular Formula | C15H24N4S • C4H4O4 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Storage | -20°C |
| InChIKey | WUYMIKDBRCCYGE-BTJKTKAUSA-N |
