For research use only. Not for therapeutic Use.
Thioproperazine（Cat No.:I009799） is an antipsychotic medication used to treat various psychiatric disorders. It belongs to the phenothiazine class of drugs and works by blocking dopamine receptors in the brain, helping to alleviate symptoms of psychosis such as hallucinations and delusions. Thioproperazine is prescribed for conditions like schizophrenia, bipolar disorder, and severe anxiety. It may also be used as an adjunct therapy in the management of certain gastrointestinal disorders.
| Catalog Number | I009799 |
| CAS Number | 316-81-4 |
| Synonyms | Thioproperazine; Cephalmin; Majeptyl; Mazeptyl; Megeptil; Sulfenazin; Vontil; Tioproferazina.;N,N-dimethyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine-2-sulfonamide |
| Molecular Formula | C22H30N4O2S2 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Soluble in DMSO, not in water |
| Storage | Room Temperature |
| IUPAC Name | N,N-dimethyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine-2-sulfonamide |
| InChI | InChI=1S/C22H30N4O2S2/c1-23(2)30(27,28)18-9-10-22-20(17-18)26(19-7-4-5-8-21(19)29-22)12-6-11-25-15-13-24(3)14-16-25/h4-5,7-10,17H,6,11-16H2,1-3H3 |
| InChIKey | VZYCZNZBPPHOFY-UHFFFAOYSA-N |
| SMILES | CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C |
| Reference | </br>1:[Changes in plasma prolactin and magnesium in male rats treated with thioproperazine and/or bromocriptine]. Marois G, Henrotte JG, Elie C, Franck G.Ann Endocrinol (Paris). 1985;46(6):399-405. French. PMID: 2873785 </br>2:Treatment of ulcerative colitis with thioproperazine. Lechin F, van der Dijs B, Insausti CL, Gómez F.J Clin Gastroenterol. 1982 Oct;4(5):445-9. PMID: 6129273 </br>3:[Inhibition of nidation in mice by modification of the environment and pheromones. Re-establishment by prolactin and thioproperazine]. Marois G.Ann Endocrinol (Paris). 1982;43(1):41-52. French. PMID: 6127981 </br>4:On the use of clonidine and thioproperazine in a woman with Gilles de la Tourette/’s disease. Lechin F, van der Dijs B, Gómez F, Acosta E, Arocha L.Biol Psychiatry. 1982 Jan;17(1):103-8. PMID: 6120723 </br>5:The use of thioproperazine, a phenothiazine derivative, as a ligand for neuroleptic receptors–II. In vivo studies. Boireau A, Blanchard JC, Garret C, Julou L.Biochem Pharmacol. 1980 Nov 1;29(21):2939-42. No abstract available. PMID: 6109532 </br>6:The use of thioproperazine, a phenothiazine derivative, as a ligand for neuroleptic receptors–I. In vitro studies. Blanchard JC, Boireau A, Garret C, Julou L.Biochem Pharmacol. 1980 Nov 1;29(21):2933-8. No abstract available. PMID: 6109531 </br>7:Effects of thioproperazine and sulpiride on the locomotor rhythms in the decorticate cat. Pointis D, Borenstein P.Psychopharmacology (Berl). 1979 Feb 28;60(3):271-6. PMID: 35804 </br>8:[Comparative study using double-blind method of sultopride and thioproperazine]. Sizaret P, Moreau C.Encephale. 1977;3(2):111-20. French. PMID: 19230 </br>9:Effects of thioproperazine and apomorphine on dopamine synthesis in the mesocortical dopaminergic systems. Scatton B, Thierry AM, Glowinski J, Julou L.Brain Res. 1975 May 2;88(2):389-93. No abstract available. PMID: 238717 </br>10:[Thioproperazine and transferred eggs on the rat (author/’s transl)]. Marois M, Elie C.Steroids Lipids Res. 1974;5(4):240-9. French. No abstract available. PMID: 4156437 |
