For research use only. Not for therapeutic Use.
Thonningianin B is an antioxidant and an autophagy enhancer[1][2].
Thonningianin B shows strong scavenging action against the DPPH radical. The DPPH radical is scavenged completely by a 34.5 µM solution of Thonningianin B. In a separate experiment, an IC50 value of Thonningianin B is determined to be 21 μM[1].
Thonningianin B (0-100 μM; 24 h) inhibits BV-2 cell viability with an IC50 of 46.74 μM[2].
Thonningianin B (10 μM; 24 h) significantly improves the ratio of LC3-II/LC3-I and the average number of GFP-LC3 puncta per cell in BV-2 cells[2].
| Catalog Number | I041259 |
| CAS Number | 271579-12-5 |
| Synonyms | (10S,11R,12R,13S,15R)-13-[3,5-dihydroxy-4-(3-phenylpropanoyl)phenoxy]-3,4,5,11,12,21,22,23-octahydroxy-9,14,17-trioxatetracyclo[17.4.0.02,7.010,15]tricosa-1(23),2,4,6,19,21-hexaene-8,18-dione |
| Molecular Formula | C35H30O17 |
| Purity | ≥95% |
| InChI | InChI=1S/C35H30O17/c36-17(7-6-13-4-2-1-3-5-13)25-18(37)8-14(9-19(25)38)50-35-31(46)30(45)32-22(51-35)12-49-33(47)15-10-20(39)26(41)28(43)23(15)24-16(34(48)52-32)11-21(40)27(42)29(24)44/h1-5,8-11,22,30-32,35,37-46H,6-7,12H2/t22-,30-,31-,32-,35-/m1/s1 |
| InChIKey | UJNCWORGHSATHA-XWSAIMBSSA-N |
| SMILES | C1C2C(C(C(C(O2)OC3=CC(=C(C(=C3)O)C(=O)CCC4=CC=CC=C4)O)O)O)OC(=O)C5=CC(=C(C(=C5C6=C(C(=C(C=C6C(=O)O1)O)O)O)O)O)O |
| Reference | [1]. Ohtani II, et al. Thonningianins A and B, new antioxidants from the African medicinal herb Thonningia sanguinea. J Nat Prod. 2000 May;63(5):676-9. [2]. Zhou XG, et al. Targeting microglial autophagic degradation of the NLRP3 inflammasome for identification of thonningianin A in Alzheimer’s disease. Inflamm Regen. 2022 Aug 3;42(1):25. |
