Thonzylamine free base

For research use only. Not for therapeutic Use.

  • CAT Number: I037252
  • CAS Number: 91-85-0
  • Molecular Formula: C16H22N4O
  • Molecular Weight: 286.38
  • Purity: 98%
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Thonzylamine Free Base(CAT: I037252) is a compound known as a histamine antagonist. Histamine antagonists, also known as antihistamines, are drugs that block the activity of histamine receptors in the body. Histamine is a chemical released during allergic reactions and can cause symptoms such as itching, sneezing, and watery eyes. By inhibiting the action of histamine, thonzylamine free base can help alleviate these allergic symptoms.


Catalog Number I037252
CAS Number 91-85-0
Synonyms

Thonzylamine Free Base; BRN0284655; BRN-0284655; BRN 0284655; NCIC60708; NCI C60708; NCI-C60708

Molecular Formula C16H22N4O
Purity 98%
Target Neuronal Signaling
Solubility To be determined
Appearance Solid powder
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name 1,2-Ethanediamine, N-((4-methoxyphenyl)methyl)-N',N'-dimethyl-N-2-pyrimidinyl-
InChI InChI=1S/C16H22N4O/c1-19(2)11-12-20(16-17-9-4-10-18-16)13-14-5-7-15(21-3)8-6-14/h4-10H,11-13H2,1-3H3
InChIKey GULNIHOSWFYMRN-UHFFFAOYSA-N
SMILES CN(C)CCN(CC1=CC=C(OC)C=C1)C2=NC=CC=N2
Reference

1: Sabry SM, Abdel-Hay MH, Barary MH, Belal TS. Sensitive spectrofluorimetric and spectrophotometric methods for the determination of thonzylamine hydrochloride in pharmaceutical preparations based on coupling with dimethylbarbituric acid in presence of dicyclohexylcarbodiimide. J Pharm Biomed Anal. 2000 Mar;22(2):257-64. doi: 10.1016/s0731-7085(99)00261-7. PMID: 10719908.
2: Zhou S, Huang G, Chen G. Design, synthesis and biological activity of a novel ethylenediamine derivatives as H1 receptor antagonists. Bioorg Med Chem. 2019 Dec 15;27(24):115127. doi: 10.1016/j.bmc.2019.115127. Epub 2019 Nov 1. PMID: 31703894.
3: DUCA CJ, ROTHLAUF MV, SCUDI JV. Further studies on thonzylamine in treatment of experimental tuberculosis. Proc Soc Exp Biol Med. 1951 Aug;77(4):641-3. doi: 10.3181/00379727-77-18876. PMID: 14891823.
4: DREYER NB, SLAVIN WJ. Effect of an antihistaminic drug (thonzylamine) on uterine contractility. J Am Med Womens Assoc. 1954 Feb;9(2):35-8. PMID: 13142908.
5: ARMINIO JJ, SWEET CC. The prophylaxis and treatment of the common cold with neohetramine (thonzylamine hydrochloride). Ind Med Surg. 1949 Dec;18(12):509-11. PMID: 15393969.
6: GRAHAM JD. Substituted ethylenediamines related to thonzylamine. Arch Int Pharmacodyn Ther. 1960 Jan 1;123:419-29. PMID: 13828806.
7: LANDIS C, ZUBIN J. The alleged sedative effect of thonzylamine hydrochloride (neoheteramine). J Lab Clin Med. 1951 Dec;38(6):873-80. PMID: 14889075.
8: Mossini F, Maggiali C, Morini G, Impicciatore M, Morini G, Molina E. Composti 4-[benzil-(2-dimetilaminoetil)amino]-pirimidinici antagonisti selettivi dei recettori H1-istaminici [4-[Benzyl-(2-dimethylaminoethyl)amino]pyrimidine compounds with selective antagonistic activity against H1-histamine receptors]. Farmaco Sci. 1984 Mar;39(3):189-99. Italian. PMID: 6143687.
9: REINHARD JF, SCUDI JV. Daily administration of massive oral doses of thonzylamine hydro-chloride. Proc Soc Exp Biol Med. 1950 May;74(1):190-1. PMID: 15430430.
10: Nakano S, Taniguchi H, Furuhashi T. [Fluorometric analysis with o-aminothiophenol. II. Fluorometric determination of thonzylamine hydrochloride]. Yakugaku Zasshi. 1972 Apr;92(4):411-6. Japanese. doi: 10.1248/yakushi1947.92.4_411. PMID: 5065436.

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