Thymohydroquinone

• CAT Number: I037277
• CAS Number: 2217-60-9
• Molecular Formula: C10H14O2
• Molecular Weight: 166.22
• Purity: 98%
• Synonyms: NSC 34803, Thymohydroquinone
• Target: Plants
• Solubility: Soluble in DMSO
• Appearance: Crystalline solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 2-methyl-5-(1-methylethyl)-1,4-benzenediol
• InChI: InChI=1S/C10H14O2/c1-6(2)8-5-9(11)7(3)4-10(8)12/h4-6,11-12H,1-3H3
• InChIKey: OQIOHYHRGZNZCW-UHFFFAOYSA-N
• SMILES: CC(C)C1=C(O)C=C(C)C(O)=C1

Thymohydroquinonee (Cat.No:I037277) is a quinone that has been found in N. sativa seeds and has diverse biological activities. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radicals and inhibits growth of A2780, OVCAR-8, CIS-A2780 ovarian cancer cells, and immortalized human ovarian epithelial cells. It is also active against P. falciparum in vitro.

Reference

1. Tesarova, H., Svobodova, B., Kokoska, L., et al. Determination of oxygen radical absorbance capacity of black cumin (Nigella sativa) seed quinone compounds. Nat. Prod. Commun. 6(2), 213-216 (2011).
2. Johnson-Ajinwo, O.R., Ullah, I., Mbye, H., et al. The synthesis and evaluation of thymoquinone analogues as anti-ovarian cancer and antimalarial agents. Bioorg. Med. Chem. Lett. 28(7), 1219-1222 (2018).