Thymoquinone

• CAT Number: R059643
• CAS Number: 490-91-5
• Molecular Formula: C10H12O2
• Molecular Weight: 164.204
• Purity: ≥95%
• Synonyms: 2-Methyl-5-(1-methylethyl)-2,5-cyclohexadiene-1,4-dione; p-Mentha-3,6-?diene-2,5-dione; 2-Isopropyl-5-methyl-1,4-benzoquinone; 2-Isopropyl-5-methyl-p-benzoquinone; 2-Isopropyl-5-methylbenzoquinone; 2-Methyl-5-isopropyl-1,4-benzoquinone; 2-Methyl-5-is
• Storage: -20°C
• IUPAC Name: 2-methyl-5-propan-2-ylcyclohexa-2,5-diene-1,4-dione
• InChI: InChI=1S/C10H12O2/c1-6(2)8-5-9(11)7(3)4-10(8)12/h4-6H,1-3H3
• InChIKey: KEQHJBNSCLWCAE-UHFFFAOYSA-N
• SMILES: CC1=CC(=O)C(=CC1=O)C(C)C

The black seeds of Nigella have long been ingested to treat a broad range of diseases, including inflammation and cancer. Thymoquinone is a natural phytochemical isolated from the seeds of N. sativa. It has anti-<wbr></wbr>inflammatory effects, blocking the synthesis of leukotrienes. Thymoquinone inhibits the growth of leukemia cells (IC50 = 1.5 μg/ml), inducing apoptosis by down-<wbr></wbr>regulating the expression of Bcl-<wbr></wbr>2 while up-<wbr></wbr>regulating Bax expression. In addition to blocking cell proliferation and triggering apoptosis, thymoquinone (15 μM) suppresses STAT3-<wbr></wbr>regulated gene expression and prevents angiogenesis.