For research use only. Not for therapeutic Use.
THZ1 Hydrochloride（Cat No.:I005773）is a potent and selective inhibitor of cyclin-dependent kinase 7 (CDK7), an enzyme crucial for transcription and cell cycle regulation. By inhibiting CDK7, THZ1 disrupts the phosphorylation of RNA polymerase II, thereby blocking transcription and reducing the expression of genes essential for cancer cell survival. It has shown promise in preclinical studies for targeting cancers with high transcriptional dependencies, such as triple-negative breast cancer and neuroblastoma. THZ1 Hydrochloride is valuable in cancer research for understanding transcriptional regulation and exploring therapeutic interventions.
| Catalog Number | I005773 |
| Synonyms | (E)-N-(3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide hydrochloride |
| Molecular Formula | C31H29Cl2N7O2 |
| Purity | ≥95% |
| Target | Cyclin-Dependent Kinases |
| Solubility | >30.1mg/mL in DMSO |
| Storage | Store at -20°C |
| IC50 | 3.2 nM (Kd for CDK7) |
| Reference | [1]. Nicholas Kwiatkowski, et al. Targeting transcription regulation in cancer with a covalent CDK7 inhibitor. Nature (2014) doi:10.1038/nature13393 |
