Tiagabine hydrochloride

• CAT Number: I009803
• CAS Number: 145821-59-6
• Molecular Formula: C20H26ClNO2S2
• Molecular Weight: 412.01
• Purity: ≥95%
• Synonyms: NO-329; NO329; NO 329; NNC-05-0328; NO-05-0328; Tiagabine hydrochloride; brand name Gabitril;(R)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-en-1-yl)piperidine-3-carboxylic acid hydrochloride
• Target: Neuronal Signaling
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: (3R)-1-[4,4-bis(3-methylthiophen-2-yl)but-3-enyl]piperidine-3-carboxylic acid;hydrochloride
• InChI: InChI=1S/C20H25NO2S2.ClH/c1-14-7-11-24-18(14)17(19-15(2)8-12-25-19)6-4-10-21-9-3-5-16(13-21)20(22)23;/h6-8,11-12,16H,3-5,9-10,13H2,1-2H3,(H,22,23);1H/t16-;/m1./s1
• InChIKey: YUKARLAABCGMCN-PKLMIRHRSA-N
• SMILES: CC1=C(SC=C1)C(=CCCN2CCC[C@H](C2)C(=O)O)C3=C(C=CS3)C.Cl

Tiagabine hydrochloride (CAT: I009803) is a pharmaceutical compound primarily used as an antiepileptic drug. It acts as a selective gamma-aminobutyric acid (GABA) reuptake inhibitor, increasing the concentration of GABA in the brain. GABA is an inhibitory neurotransmitter that helps regulate the excitability of neurons. By inhibiting GABA reuptake, tiagabine hydrochloride enhances GABAergic neurotransmission, resulting in reduced neuronal excitability and seizure control. It is commonly prescribed as an adjunctive treatment for partial seizures in patients with epilepsy who have not responded adequately to other antiepileptic medications.