Tiagabine

• CAT Number: I000559
• CAS Number: 115103-54-3
• Molecular Formula: C20H25NO2S2
• Molecular Weight: 375.55
• Purity: ≥95%
• Target: GABA reuptake inhibitor
• Solubility: 10 mM in DMSO
• Storage: -20°C

Tiagabine (CAT: I000559), also known as NO328, is a pharmaceutical drug used for the treatment of epilepsy. It acts as a selective inhibitor of the gamma-aminobutyric acid (GABA) reuptake transporter, known as GAT-1, resulting in increased levels of GABA in the synaptic cleft. GABA is an inhibitory neurotransmitter that helps regulate neuronal excitability. By blocking its reuptake, tiagabine enhances GABAergic transmission and helps reduce abnormal neuronal activity associated with epilepsy. It is primarily prescribed as an adjunctive therapy for partial seizures in individuals with epilepsy.

Reference

[1]. Pollack, M.H., et al., The selective GABA reuptake inhibitor tiagabine for the treatment of generalized anxiety disorder: results of a placebo-controlled study. J Clin Psychiatry, 2005. 66(11): p. 1401-8.

[2]. Sheehan, D.V., et al., An open-label study of tiagabine in panic disorder. Psychopharmacol Bull, 2007. 40(3): p. 32-40.

[3]. Henjum, S. and B. Hassel, High-affinity GABA uptake and GABA-metabolizing enzymes in pig forebrain white matter: a quantitative study. Neurochem Int, 2007. 50(2): p. 365-70.