For research use only. Not for therapeutic Use.
Tiamulin Fumarate（Cat No.:I004057）is a semi-synthetic pleuromutilin antibiotic primarily used in veterinary medicine to treat respiratory and gastrointestinal infections in swine and poultry. It exhibits strong activity against Gram-positive bacteria and certain mycoplasma species by inhibiting protein synthesis through binding to the 50S ribosomal subunit. Tiamulin is effective against pathogens like Mycoplasma hyopneumoniae and Lawsonia intracellularis, which cause economically significant diseases in livestock. Known for its high tissue penetration and safety profile, tiamulin fumarate is a valuable agent in promoting animal health and productivity in agricultural settings.
| Catalog Number | I004057 |
| CAS Number | 55297-96-6 |
| Synonyms | 81723 Hfu;SQ 22,947 |
| Molecular Formula | C28H47NO4S • C4H4O4 |
| Purity | ≥95% |
| Target | Bacterial |
| Solubility | DMSO:50mg/mL |
| Storage | Room temperature |
| IUPAC Name | (E)-but-2-enedioic acid;[(1S,2R,3S,4S,6R,7R,8R,14R)-4-ethenyl-3-hydroxy-2,4,7,14-tetramethyl-9-oxo-6-tricyclo[5.4.3.01,8]tetradecanyl] 2-[2-(diethylamino)ethylsulfanyl]acetate |
| InChI | InChI=1S/C28H47NO4S.C4H4O4/c1-8-26(6)17-22(33-23(31)18-34-16-15-29(9-2)10-3)27(7)19(4)11-13-28(20(5)25(26)32)14-12-21(30)24(27)28;5-3(6)1-2-4(7)8/h8,19-20,22,24-25,32H,1,9-18H2,2-7H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t19-,20+,22-,24+,25+,26-,27+,28+;/m1./s1 |
| InChIKey | YXQXDXAHCSEVSD-GCYNEOGWSA-N |
| SMILES | CCN(CC)CCSCC(=O)O[C@@H]1C[C@@]([C@H]([C@@H]([C@@]23CC[C@H]([C@@]1([C@@H]2C(=O)CC3)C)C)C)O)(C)C=C.C(=C/C(=O)O)\C(=O)O |
| Reference | <p style=/line-height:25px/> <br>[2]. Dreyfuss J, et al. Metabolism of tritium- and carbon-14-labeled tiamulin in dogs, rats, and pigs. J Antibiot (Tokyo). 1979 May;32(5):496-503. <br>[3]. Islam KM, et al. The activity and compatibility of the antibiotic tiamulin with other drugs in poultry medicine–A review. Poult Sci. 2009 Nov;88(11):2353-9. </p> |
