TIC10 Analogue

• CAT Number: I003497
• CAS Number: 41276-02-2
• Molecular Formula: C24H26N4O
• Molecular Weight: 386.49
• Purity: ≥95%
• Storage: 3 years-20°Cpowder
• SMILES: CC1=CC=CC=C1CN2C3=C(CN(CC3)CC4=CC=CC=C4)C(=O)N5C2=NCC5

TIC10 Analogue is an analogue of TIC10, which inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. Phase 1/2.

Reference

[1] Allen JE, et al. Sci Transl Med, 2013, 5(171), 171ra17.