TIE-2/VEGFR-2 kinase-IN-1

• CAT Number: I015379
• CAS Number: 453590-24-4
• Molecular Formula: C13H11N3O2
• Molecular Weight: 241.25
• Purity: ≥95%
• Synonyms: 6-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-amine
• InChI: InChI=1S/C13H11N3O2/c1-17-9-4-2-8(3-5-9)11-6-10-12(14)15-7-16-13(10)18-11/h2-7H,1H3,(H2,14,15,16)
• InChIKey: DIJLFIHLUYAZCI-UHFFFAOYSA-N
• SMILES: COC1=CC=C(C=C1)C2=CC3=C(N=CN=C3O2)N

TIE-2/VEGFR-2 kinase-IN-1 is used for the synthesis of TIE-2 and/or VEGFR-2 inhibitors, extracted from patent WO2003022852, example 14. TIE-2/VEGFR-2 kinase-IN-1 is used for the study of diseases associated with inappropriate angiogenesis[1].
Angiopoieten 1 is a ligand for the endotheiium-specific receptor tyrosine kinase, TIE-2 is a novel angiogenic factor[1].Inhibition of TIE-2 is expected to serve to disrupt remodeling and maturation of new vasculature initiated by angiogenesis thereby disrupting the angiogenic process. Inhibition at the kinase domain binding site of VEGFR-2 would block phosphorylation of tyrosine residues and serve to disrupt initiation of angiogenesis.

Reference

[1]. Jerry Leroy Adams, et al. Furo-and thienopyrimidine derivatives as angiogenesis inhibitors. Patent WO2003022852.