For research use only. Not for therapeutic Use.
Tie2 kinase inhibitor(Cat No.:I012043)is a small molecule that targets the Tie2 receptor tyrosine kinase, playing a critical role in angiogenesis and vascular stability. By inhibiting Tie2 signaling, these inhibitors can disrupt abnormal blood vessel formation, making them potential therapeutic agents for treating cancer, ocular diseases, and inflammation-related disorders. Tie2 kinase inhibitors can block tumor growth by reducing blood supply to the tumor microenvironment. Research is ongoing to explore their use in combination therapies and to better understand their impact on various vascular-related diseases and conditions.
Catalog Number | I012043 |
CAS Number | 948557-43-5 |
Synonyms | 4-[4-(6-Methoxy-2-naphthalenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]pyridine; |
Molecular Formula | C26H21N3O2S |
Purity | ≥95% |
Target | Tie |
Solubility | >22mg/mL in DMSO |
Storage | Store at RT |
IUPAC Name | 4-[4-(6-methoxynaphthalen-2-yl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine |
InChI | InChI=1S/C26H21N3O2S/c1-31-22-8-5-19-15-21(4-3-20(19)16-22)25-24(17-11-13-27-14-12-17)28-26(29-25)18-6-9-23(10-7-18)32(2)30/h3-16H,1-2H3,(H,28,29) |
InChIKey | SINQIEAULQKUPD-UHFFFAOYSA-N |
SMILES | COC1=CC2=C(C=C1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)S(=O)C)C5=CC=NC=C5 |
Reference | 1. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4756-60. Epub 2007 Jun 27. |