Tie2 Kinase Inhibitor

For research use only. Not for therapeutic Use.

  • CAT Number: I012043
  • CAS Number: 948557-43-5
  • Molecular Formula: C26H21N3O2S
  • Molecular Weight: 439.53
  • Purity: ≥95%
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Tie2 kinase inhibitor(Cat No.:I012043)is a small molecule that targets the Tie2 receptor tyrosine kinase, playing a critical role in angiogenesis and vascular stability. By inhibiting Tie2 signaling, these inhibitors can disrupt abnormal blood vessel formation, making them potential therapeutic agents for treating cancer, ocular diseases, and inflammation-related disorders. Tie2 kinase inhibitors can block tumor growth by reducing blood supply to the tumor microenvironment. Research is ongoing to explore their use in combination therapies and to better understand their impact on various vascular-related diseases and conditions.


Catalog Number I012043
CAS Number 948557-43-5
Synonyms

4-[4-(6-Methoxy-2-naphthalenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]pyridine;

Molecular Formula C26H21N3O2S
Purity ≥95%
Target Tie
Solubility >22mg/mL in DMSO
Storage Store at RT
IUPAC Name 4-[4-(6-methoxynaphthalen-2-yl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine
InChI InChI=1S/C26H21N3O2S/c1-31-22-8-5-19-15-21(4-3-20(19)16-22)25-24(17-11-13-27-14-12-17)28-26(29-25)18-6-9-23(10-7-18)32(2)30/h3-16H,1-2H3,(H,28,29)
InChIKey SINQIEAULQKUPD-UHFFFAOYSA-N
SMILES COC1=CC2=C(C=C1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)S(=O)C)C5=CC=NC=C5
Reference

1. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4756-60. Epub 2007 Jun 27.
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Pyridinylimidazole inhibitors of Tie2 kinase.
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Semones M(1), Feng Y, Johnson N, Adams JL, Winkler J, Hansbury M.
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Author information:<br>
(1)GlaxoSmithKline, Collegeville, PA 19426, USA. [email protected]
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This communication details the evolution of the screening lead SB-203580, a known
CSBP/p38 kinase inhibitor, into a potent and selective Tie2 tyrosine kinase
inhibitor. The optimized compound 5 showed efficacy in an in vivo model of
angiogenesis and a MOPC-315 plasmacytoma xenograft model.

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