Tigemonam

• CAT Number: I013245
• CAS Number: 102507-71-1
• Molecular Formula: C₁₂H₁₅N₅O₉S₂
• Molecular Weight: 437.41
• Purity: ≥95%
• Target: Bacterial
• Solubility: DMSO
• IUPAC Name: 2-[(Z)-[1-(2-amino-1,3-thiazol-4-yl)-2-[[(3S)-2,2-dimethyl-4-oxo-1-sulfooxyazetidin-3-yl]amino]-2-oxoethylidene]amino]oxyacetic acid
• InChI: InChI=1S/C12H15N5O9S2/c1-12(2)8(10(21)17(12)26-28(22,23)24)15-9(20)7(16-25-3-6(18)19)5-4-27-11(13)14-5/h4,8H,3H2,1-2H3,(H2,13,14)(H,15,20)(H,18,19)(H,22,23,24)/b16-7-/t8-/m1/s1
• InChIKey: VAMSVIZLXJOLHZ-QWFSEIHXSA-N
• SMILES: CC1([C@@H](C(=O)N1OS(=O)(=O)O)NC(=O)/C(=N\OCC(=O)O)/C2=CSC(=N2)N)C

Tigemonam（Cat No.:I013245）is a monobactam antibiotic effective against various Gram-negative bacteria, particularly targeting infections caused by Enterobacteriaceae. It works by inhibiting bacterial cell wall synthesis, resulting in cell death, and has shown efficacy in treating respiratory and urinary tract infections. Unlike many other antibiotics, tigemonam demonstrates good stability against certain beta-lactamases, making it a valuable option in cases of resistance. With an oral formulation, it offers convenient administration for outpatient treatment. Tigemonam’s specificity and effectiveness contribute to its potential role in combating resistant bacterial infections.

Reference

[1]. Rylander M, et al. Comparative in-vitro activity of tigemonam, a new monobactam. J Antimicrob Chemother. 1988 Sep;22(3):307-13.[2]. Clark JM, et al. In vivo evaluation of tigemonam, a novel oral monobactam. Antimicrob Agents Chemother. 1987 Feb;31(2):226-9.