For research use only. Not for therapeutic Use.
Tildipirosin（Cat No.:I003170）is a long-acting macrolide antibiotic used in veterinary medicine, specifically for treating respiratory infections in cattle and swine caused by pathogens like Mannheimia haemolytica, Pasteurella multocida, and Actinobacillus pleuropneumoniae. It works by inhibiting protein synthesis in bacteria, leading to cell death. Tildipirosin’s extended half-life allows for single-dose administration, which improves compliance and reduces handling stress in animals. Known for its efficacy and prolonged action, it is a valuable treatment option in livestock management, supporting animal health and productivity with minimal doses.
| Catalog Number | I003170 |
| CAS Number | 328898-40-4 |
| Synonyms | 20-deoxo-23-deoxy-5-O-[3,6-dideoxy-3-(dimethylamino)-β-D-glucopyranosyl]-20,23-di-1-piperidinyl-tylonolide |
| Molecular Formula | C₄₁H₇₁N₃O₈ |
| Purity | ≥95% |
| Target | Bacterial |
| Solubility | 10 mM in DMSO |
| Storage | 2-8°C |
| IUPAC Name | (4R,5S,6S,7R,9R,11E,13E,15R,16R)-6-[(2R,3R,4S,5S,6R)-4-(dimethylamino)-3,5-dihydroxy-6-methyloxan-2-yl]oxy-16-ethyl-4-hydroxy-5,9,13-trimethyl-7-(2-piperidin-1-ylethyl)-15-(piperidin-1-ylmethyl)-1-oxacyclohexadeca-11,13-diene-2,10-dione |
| InChI | InChI=1S/C41H71N3O8/c1-8-35-32(26-44-20-13-10-14-21-44)23-27(2)15-16-33(45)28(3)24-31(17-22-43-18-11-9-12-19-43)40(29(4)34(46)25-36(47)51-35)52-41-39(49)37(42(6)7)38(48)30(5)50-41/h15-16,23,28-32,34-35,37-41,46,48-49H,8-14,17-22,24-26H2,1-7H3/b16-15+,27-23+/t28-,29+,30-,31+,32-,34-,35-,37+,38-,39-,40-,41+/m1/s1 |
| InChIKey | HNDXPZPJZGTJLJ-UEJFNEDBSA-N |
| SMILES | CCC1C(C=C(C=CC(=O)C(CC(C(C(C(CC(=O)O1)O)C)OC2C(C(C(C(O2)C)O)N(C)C)O)CCN3CCCCC3)C)C)CN4CCCCC4 |
| Reference | </br>1:Efficacy of tildipirosin metaphylaxis for the prevention of respiratory disease, otitis and mortality in pre-weaned Holstein calves. Teixeira AG, McArt JA, Bicalho RC.Vet J. 2017 Jan;219:44-48. doi: 10.1016/j.tvjl.2016.12.004. Epub 2016 Dec 12. PMID: 28093111 </br>2:Clinical disease and lung lesions in calves experimentally inoculated with Histophilus somni five days after metaphylactic administration of tildipirosin or tulathromycin. Confer AW, Snider TA, Taylor JD, Montelongo M, Sorensen NJ.Am J Vet Res. 2016 Apr;77(4):358-66. doi: 10.2460/ajvr.77.4.358. PMID: 27027834 </br>3:Pharmacokinetics of tildipirosin in pig tonsils. Torres F, Santamaria R, Jimenez M, Menjón R, Ibanez A, Collell M, Azlor O, Fraile L.J Vet Pharmacol Ther. 2016 Apr;39(2):199-201. doi: 10.1111/jvp.12258. Epub 2015 Aug 12. PMID: 26935349 </br>4:A microbiological assay to estimate the antimicrobial activity of parenteral tildipirosin against foodborne pathogens and commensals in the colon of beef cattle and pigs. Rose M, Pridmore A, Shaw A, Wilhelm C, Menge M, Kilp S, Röpke R, Nürnberger M.J Vet Pharmacol Ther. 2016 Jun;39(3):277-86. doi: 10.1111/jvp.12277. Epub 2015 Nov 5. PMID: 26538405 </br>5:Pulmonary lesions and clinical disease response to Mannheimia haemolytica challenge 10 days following administration of tildipirosin or tulathromycin. Amrine DE, White BJ, Larson RL, Mosier DA.J Anim Sci. 2014 Jan;92(1):311-9. doi: 10.2527/jas.2013-6577. Epub 2013 Nov 15. PMID: 24243906 Free Article</br>6:Inhibition of protein synthesis on the ribosome by tildipirosin compared with other veterinary macrolides. Andersen NM, Poehlsgaard J, Warrass R, Douthwaite S.Antimicrob Agents Chemother. 2012 Nov;56(11):6033-6. doi: 10.1128/AAC.01250-12. Epub 2012 Aug 27. PMID: 22926570 Free PMC Article</br>7:Visualizing the 16-membered ring macrolides tildipirosin and tilmicosin bound to their ribosomal site. Poehlsgaard J, Andersen NM, Warrass R, Douthwaite S.ACS Chem Biol. 2012 Aug 17;7(8):1351-5. doi: 10.1021/cb300105p. Epub 2012 May 14. PMID: 22563863 </br>8:Pharmacokinetics of tildipirosin in porcine plasma, lung tissue, and bronchial fluid and effects of test conditions on in vitro activity against reference strains and field isolates of Actinobacillus pleuropneumoniae. Rose M, Menge M, Bohland C, Zschiesche E, Wilhelm C, Kilp S, Metz W, Allan M, Röpke R, Nürnberger M.J Vet Pharmacol Ther. 2013 Apr;36(2):140-53. doi: 10.1111/j.1365-2885.2012.01397.x. Epub 2012 Apr 15. PMID: 22500881 </br>9:Increased MICs of gamithromycin and tildipirosin in the presence of the genes erm(42) and msr(E)-mph(E) for bovine Pasteurella multocida and Mannheimia haemolytica. Michael GB, Eidam C, Kadlec K, Meyer K, Sweeney MT, Murray RW, Watts JL, Schwarz S.J Antimicrob Chemother. 2012 Jun;67(6):1555-7. doi: 10.1093/jac/dks076. Epub 2012 Mar 7. No abstract available. PMID: 22398653 </br>10:Pharmacokinetics of tildipirosin in bovine plasma, lung tissue, and bronchial fluid (from live, nonanesthetized cattle). Menge M, Rose M, Bohland C, Zschiesche E, Kilp S, Metz W, Allan M, Röpke R, Nürnberger M.J Vet Pharmacol Ther. 2012 Dec;35(6):550-9. doi: 10.1111/j.1365-2885.2011.01349.x. Epub 2011 Dec 21. PMID: 22188102 |
