For research use only. Not for therapeutic Use.
Tilmicosin(Cat No.:A000441)is a broad-spectrum macrolide antibiotic primarily used in veterinary medicine to treat respiratory infections in cattle, swine, and poultry. It is effective against a variety of Gram-positive and Gram-negative bacteria, as well as certain mycoplasmas. Tilmicosin works by inhibiting bacterial protein synthesis, targeting the 50S ribosomal subunit. It is commonly used for conditions like pneumonia, bronchitis, and mastitis. Due to its potential cardiotoxicity, particularly in non-target species, its use is restricted in certain animals, and careful dosing is necessary for effective treatment and safety.
Catalog Number | A000441 |
CAS Number | 108050-54-0 |
Synonyms | EL 870 |
Molecular Formula | C46H80N2O13 |
Purity | ≥95% |
Target | Bacterial |
Storage | 3 years -20C powder |
IUPAC Name | (4R,5S,6S,7R,9R,11E,13E,15R,16R)-6-[(2R,3R,4S,5S,6R)-4-(dimethylamino)-3,5-dihydroxy-6-methyloxan-2-yl]oxy-7-[2-[(3S,5R)-3,5-dimethylpiperidin-1-yl]ethyl]-16-ethyl-4-hydroxy-15-[[(2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxymethyl]-5,9,13-trimethyl-1-oxacyclohexadeca-11,13-diene-2,10-dione |
InChI | InChI=1S/C46H80N2O13/c1-13-36-33(24-57-46-44(56-12)43(55-11)40(53)31(8)59-46)19-25(2)14-15-34(49)28(5)20-32(16-17-48-22-26(3)18-27(4)23-48)42(29(6)35(50)21-37(51)60-36)61-45-41(54)38(47(9)10)39(52)30(7)58-45/h14-15,19,26-33,35-36,38-46,50,52-54H,13,16-18,20-24H2,1-12H3/b15-14+,25-19+/t26-,27+,28-,29+,30-,31-,32+,33-,35-,36-,38+,39-,40-,41-,42-,43-,44-,45+,46-/m1/s1 |
InChIKey | JTSDBFGMPLKDCD-XVFHVFLVSA-N |
SMILES | CC[C@@H]1[C@H](/C=C(/C=C/C(=O)[C@@H](C[C@@H]([C@@H]([C@H]([C@@H](CC(=O)O1)O)C)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)C)O)N(C)C)O)CCN3C[C@@H](C[C@@H](C3)C)C)C)\C)CO[C@H]4[C@@H]([C@@H]([C@@H]([C@H](O4)C)O)OC)OC |
Reference | <p>Lovmar, Martin, and Tanel Tenson. /The Mechanism of Action of Macrolides, Lincosamides and Streptogramin B Reveals the Nascent Peptide Exit Path in the Ribosome./<em>Journal of Molecular Microbiology</em> 330.5 (2003): 1005-014.</p></span></p> |