Tilorone

• CAT Number: I040007
• CAS Number: 27591-97-5
• Molecular Formula: C25H34N2O3
• Molecular Weight: 410.55
• Purity: ≥95%
• Synonyms: 2,7-bis[2-(diethylamino)ethoxy]fluoren-9-one
• InChI: InChI=1S/C25H34N2O3/c1-5-26(6-2)13-15-29-19-9-11-21-22-12-10-20(30-16-14-27(7-3)8-4)18-24(22)25(28)23(21)17-19/h9-12,17-18H,5-8,13-16H2,1-4H3
• InChIKey: MPMFCABZENCRHV-UHFFFAOYSA-N
• SMILES: CCN(CC)CCOC1=CC2=C(C=C1)C3=C(C2=O)C=C(C=C3)OCCN(CC)CC

Tilorone (Cat No.: I040007) is a synthetic small-molecule antiviral and immunomodulatory agent known as an interferon inducer. It stimulates the production of type I interferons, enhancing the immune response against viral infections. Tilorone has demonstrated broad-spectrum antiviral activity against RNA and DNA viruses, including influenza, herpes, and coronaviruses. It has been explored for its potential in treating viral infections and immune-related conditions. Due to its oral bioavailability and low toxicity, tilorone remains a subject of research for antiviral and immunomodulatory therapeutic applications.

Reference

[1]. Stringfellow D A, et al. Tilorone hydrochloride: an oral interferon-inducing agent[J]. Antimicrobial agents and chemotherapy, 1972, 2(2): 73-78.
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[2]. Ekins S, et al. Efficacy of tilorone dihydrochloride against Ebola virus infection[J]. Antimicrobial agents and chemotherapy, 2018, 62(2): 10.1128/aac. 01711-17.
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[3]. Kohler Z M, et al. Tilorone increases glucose uptake in vivo and in skeletal muscle cells by enhancing Akt2/AS160 signaling and glucose transporter levels[J]. Journal of Cellular Physiology, 2023, 238(5): 1080-1094.
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[4]. Wissing M D, et al. Small-molecule screening of PC3 prostate cancer cells identifies tilorone dihydrochloride to selectively inhibit cell growth based on cyclin-dependent kinase 5 expression[J]. Oncology reports, 2014, 32(1): 419-424.