Tinidazole

For research use only. Not for therapeutic Use.

  • CAT Number: A000726
  • CAS Number: 19387-91-8
  • Molecular Formula: C8H13N3O4S
  • Molecular Weight: 247.30
  • Purity: ≥95%
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Tinidazole(Cat No.:A000726)is an antimicrobial agent commonly used to treat protozoal and bacterial infections. It is particularly effective against infections caused by Giardia, Trichomonas, and Entamoeba histolytica. Tinidazole works by inhibiting DNA synthesis in microorganisms, leading to cell death. It is typically administered orally in tablet form and is used for conditions such as giardiasis, trichomoniasis, and amebiasis. It has a similar mechanism of action to metronidazole but offers a more convenient dosing regimen. Tinidazole is well-tolerated, with potential side effects including gastrointestinal upset and a metallic taste.


Catalog Number A000726
CAS Number 19387-91-8
Synonyms

19387-91-8; 1-(2-(Ethylsulfonyl)ethyl)-2-methyl-5-nitro-1H-imidazole; Fasigyn; Tindamax; Tinidazol

Molecular Formula C8H13N3O4S
Purity ≥95%
Target Bacterial
Solubility >11.3mg/mL in DMSO
Storage -20°C
IUPAC Name 1-(2-ethylsulfonylethyl)-2-methyl-5-nitroimidazole
InChI InChI=1S/C8H13N3O4S/c1-3-16(14,15)5-4-10-7(2)9-6-8(10)11(12)13/h6H,3-5H2,1-2H3
InChIKey HJLSLZFTEKNLFI-UHFFFAOYSA-N
SMILES CCS(=O)(=O)CCN1C(=NC=C1[N+](=O)[O-])C
Reference

1: Alfaro-Fuentes I, Castro-Ramírez R, Ortiz-Pastrana N, Medina-Guerrero RM,
Soler-Jiménez LC, Martínez-Rodríguez I, Betancourt-Lozano M, Ibarra-Castro L,
Barba-Behrens N, Fajer-ávila EJ. Novel antihelmintic activity of tinidazole
coordination compounds. Relevance of the metal ion and structural properties. J
Inorg Biochem. 2017 Nov;176:159-167. doi: 10.1016/j.jinorgbio.2017.08.013. Epub
2017 Aug 30. PubMed PMID: 28917638.

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functionalized homogeneous electrospun chitosan/poly (ε-caprolactone) hybrid
nanofiber membrane: Development, optimization and its clinical implications. Int
J Biol Macromol. 2017 Oct;103:1311-1326. doi: 10.1016/j.ijbiomac.2017.05.161.
Epub 2017 Jun 2. PubMed PMID: 28583874.
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3: Petrina MAB, Cosentino LA, Rabe LK, Hillier SL. Susceptibility of bacterial
vaginosis (BV)-associated bacteria to secnidazole compared to metronidazole,
tinidazole and clindamycin. Anaerobe. 2017 Oct;47:115-119. doi:
10.1016/j.anaerobe.2017.05.005. Epub 2017 May 15. PubMed PMID: 28522362; PubMed
Central PMCID: PMC5623164.

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4: Singh R, Ramachandra SS, Dayakara JK. Oral fixed drug eruption due to
tinidazole. Cutis. 2016 Dec;98(6):E1-E2. PubMed PMID: 28099544.
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5: Raja IM, Basavareddy A, Mukherjee D, Meher BR. Randomized, double-blind,
comparative study of oral metronidazole and tinidazole in treatment of bacterial
vaginosis. Indian J Pharmacol. 2016 Nov-Dec;48(6):654-658. doi:
10.4103/0253-7613.194843. PubMed PMID: 28066102; PubMed Central PMCID:
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6: Sharma BG, Kumar N, Nishad DK, Khare NK, Bhatnagar A. Development of microbial
trigger based oral formulation of Tinidazole and its Gamma Scintigraphy
Evaluation: A promising tool against anaerobic microbes associated GI problems.
Eur J Pharm Sci. 2016 Jun 30;89:94-104. doi: 10.1016/j.ejps.2016.04.022. Epub
2016 Apr 21. PubMed PMID: 27108116.

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7: Escobedo AA, Ballesteros J, González-Fraile E, Almirall P. A meta-analysis of
the efficacy of albendazole compared with tinidazole as treatments for Giardia
infections in children. Acta Trop. 2016 Jan;153:120-7. doi:
10.1016/j.actatropica.2015.09.023. Epub 2015 Oct 22. Review. PubMed PMID:
26476393.

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8: Lotfy HM, Hegazy MA, Mowaka S, Mohamed EH. Validated spectrophotometric
methods for simultaneous determination of Omeprazole, Tinidazole and Doxycycline
in their ternary mixture. Spectrochim Acta A Mol Biomol Spectrosc. 2016 Jan
15;153:321-32. doi: 10.1016/j.saa.2015.07.106. Epub 2015 Aug 20. PubMed PMID:
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9: Tian Y, Shen Y, Jv M. Synthesis, characterization and evaluation of
tinidazole-loaded mPEG-PDLLA (10/90) in situ gel forming system for periodontitis
treatment. Drug Deliv. 2016 Oct;23(8):2726-2735. Epub 2015 Aug 7. PubMed PMID:
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10: Tian Y, Shen Y, Jv M. Synthesis, characterization and evaluation of
tinidazole-loaded mPEG-PDLLA (10/90) in situ gel forming system for periodontitis
treatment. Drug Deliv. 2015 Aug 7:1-10. [Epub ahead of print] PubMed PMID:
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