Tinidazole-d5

• CAT Number: R012149
• CAS Number: 1216767-04-2
• Molecular Formula: C8H8D5N3O4S
• Molecular Weight: 252.30
• Purity: ≥95%
• Synonyms: 2-methyl-5-nitro-1-[2-(1,1,2,2,2-pentadeuterioethylsulfonyl)ethyl]imidazole
• InChI: InChI=1S/C8H13N3O4S/c1-3-16(14,15)5-4-10-7(2)9-6-8(10)11(12)13/h6H,3-5H2,1-2H3/i1D3,3D2
• InChIKey: HJLSLZFTEKNLFI-WNWXXORZSA-N
• SMILES: CCS(=O)(=O)CCN1C(=NC=C1[N+](=O)[O-])C

Tinidazole-d5 is the deuterium labeled Tinidazole. Tinidazole, an orally available antibacterial agent, is a 5-nitroimidazole with selective activity against anaerobic bacteria and protozoa[1].
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Reference

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
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[2]. Nord CE, et al. Tinidazole–microbiology, pharmacology and efficacy in anaerobic infections. Infection. 1983;11(1):54-60.
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