For research use only. Not for therapeutic Use.
Tipelukast, also known as KCA-757 and MN-001, is a leukotriene (LT) receptor antagonist potentially for the treatment of non-alcoholic fatty liver disease.
| Catalog Number | R014897 |
| CAS Number | 125961-82-2 |
| Synonyms | 4-[6-Acetyl-3-[3-[(4-acetyl-3-hydroxy-2-propylphenyl)thio]propoxy]-2-propylphenoxy]-butanoic Acid; 4-[6-Acetyl-3-[3-(4-acetyl-3-hydroxy-2-propylphenylthio)propoxy]-2-propylphenoxy]butyric Acid; KCA 757; MN 001 |
| Molecular Formula | C29H38O7S |
| Purity | ≥95% |
| Target | Leukotriene Receptor |
| Storage | -20°C |
| InChI | InChI=1S/C29H38O7S/c1-5-9-23-25(14-12-22(20(4)31)29(23)36-16-7-11-27(32)33)35-17-8-18-37-26-15-13-21(19(3)30)28(34)24(26)10-6-2/h12-15,34H,5-11,16-18H2,1-4H3,(H,32,33) |
| InChIKey | KPWYNAGOBXLMSE-UHFFFAOYSA-N |
| SMILES | CC(C1=CC=C(OCCCSC(C=CC(C(C)=O)=C2O)=C2CCC)C(CCC)=C1OCCCC(O)=O)=O |
| Reference | </br>1: MN 001: KCA 757, KCA-757, MN-001. Drugs R D. 2007;8(6):400-2. PubMed PMID: 17963431.</br>2: Fujimura M, Ishiura Y, Amemiya T, Myou S, Matsuda T. No involvement of lipid mediators in a guinea pig model of ultrasonically nebulized distilled water-induced bronchoconstriction. Prostaglandins Other Lipid Mediat. 2000 Jan;60(1-3):49-58. PubMed PMID: 10680775.</br>3: Rajasekaran M, Locke KW, Parsons CL. MN-001, a novel oral anti-inflammatory agent, suppresses bladder hyperactivity in a rat model. BJU Int. 2006 Aug;98(2):430-4. PubMed PMID: 16879690.</br>4: Yamada TK, Bischoff MM, Heijnen GM, Mizoguchi T, Van Kempen H. Observation of spin-polarized surface states on ultrathin bct Mn(001) films by spin-polarized scanning tunneling spectroscopy. Phys Rev Lett. 2003 Feb 7;90(5):056803. PubMed PMID: 12633385.</br>5: Bagrets A, Schmaus S, Jaafar A, Kramczynski D, Yamada TK, Alouani M, Wulfhekel W, Evers F. Single molecule magnetoresistance with combined antiferromagnetic and ferromagnetic electrodes. Nano Lett. 2012 Oct 10;12(10):5131-6. doi: 10.1021/nl301967t. PubMed PMID: 22989203.</br>6: Bayés M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2005 Jun;27(5):331-72. PubMed PMID: 16082422.</br></br> |
