For research use only. Not for therapeutic Use.
Tipifarnib S enantiomer is the S-enantiomer of Tipifarnib. Tipifarnib is a potent and specific farnesyltransferase (FTase) inhibitor with IC50 of 0.6 nM. Tipifarnib S enantiomer is the less active isomer.
| Catalog Number | I002460 |
| CAS Number | 192185-71-0 |
| Synonyms | 6-[(S)-amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2-one |
| Molecular Formula | C27H22Cl2N4O |
| Purity | ≥95% |
| InChI | InChI=1S/C27H22Cl2N4O/c1-32-16-31-15-25(32)27(30,18-6-9-20(28)10-7-18)19-8-11-24-23(13-19)22(14-26(34)33(24)2)17-4-3-5-21(29)12-17/h3-16H,30H2,1-2H3/t27-/m0/s1 |
| InChIKey | PLHJCIYEEKOWNM-MHZLTWQESA-N |
| SMILES | CN1C=NC=C1C(C2=CC=C(C=C2)Cl)(C3=CC4=C(C=C3)N(C(=O)C=C4C5=CC(=CC=C5)Cl)C)N |
| Reference | [1]. Kraus JM, et al. Rational modification of a candidate cancer drug for use against Chagas disease. J Med Chem. 2009 Mar 26;52(6):1639-47. |
