For research use only. Not for therapeutic Use.
Tipiracil hydrochloride(CAT: I002373) functions as a thymidine phosphorylase inhibitor (TPI) and is a key constituent of the anticancer drug candidate TAS-102, presently undergoing clinical trials. As a crucial component of TAS-102, Tipiracil collaborates with trifluorothymidine (FTD), a DNA-incorporating nucleoside, to impede genetic functions necessary for cancer cell proliferation. By inhibiting thymidine phosphorylase, Tipiracil maintains effective FTD blood concentrations, enhancing its anticancer potential.
| Catalog Number | I002373 |
| CAS Number | 183204-72-0 |
| Synonyms | 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1H-pyrimidine-2,4-dione;hydrochloride |
| Molecular Formula | C9H12Cl2N4O2 |
| Purity | ≥95% |
| Target | Nucleoside Antimetabolite/Analog |
| Solubility | H2O: > 10 mg/mL |
| Storage | Store at -20°C |
| InChI | InChI=1S/C9H11ClN4O2.ClH/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11;/h11H,1-4H2,(H2,12,13,15,16);1H |
| InChIKey | KGHYQYACJRXCAT-UHFFFAOYSA-N |
| SMILES | O=C1NC(C(Cl)=C(CN2C(CCC2)=N)N1)=O.[H]Cl |
| Reference | </br>1:Self-Reported Adherence to Trifluridine and Tipiracil Hydrochloride for Metastatic Colorectal Cancer: A Retrospective Cohort Study. Sugita K, Kawakami K, Yokokawa T, Sugisaki T, Takiguchi T, Aoyama T, Suzuki K, Suenaga M, Yamaguchi K, Inoue A, Machida Y, Yamaguchi T, Hama T.Oncology. 2016;91(4):224-230. Epub 2016 Aug 12. PMID: 27513940 </br>2:[Antitumor Molecular Mechanism of Trifluridine and Tipiracil Hydrochloride (TAS-102: TFTD)]. Kitao H, Matsuoka K, Iimori M, Tokunaga E, Saeki H, Oki E, Miyamoto Y, Baba H, Maehara Y.Gan To Kagaku Ryoho. 2016 Jan;43(1):8-14. Review. Japanese. PMID: 26809521 </br>3:[Initial Evaluation of the Efficacy and Safety of Tablets Containing Trifluridine and Tipiracil Hydrochloride–Safety Measures Devised by a Multidisciplinary Team Including a Pharmaceutical Outpatient Clinic]. Aimono Y, Kamoshida T, Sakamoto R, Nemoto M, Saito Y, Aoyama Y, Maruyama T.Gan To Kagaku Ryoho. 2015 Jul;42(7):817-20. Japanese. PMID: 26197742 |
