Tipiracil

• CAT Number: I002374
• CAS Number: 183204-74-2
• Molecular Formula: C9H11ClN4O2
• Molecular Weight: 242.66
• Purity: ≥95%
• Target: thymidine phosphorylase
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IUPAC Name: 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1H-pyrimidine-2,4-dione
• InChI: 1S/C9H11ClN4O2/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11/h11H,1-4H2,(H2,12,13,15,16)
• InChIKey: QQHMKNYGKVVGCZ-UHFFFAOYSA-N
• SMILES: C1CC(=N)N(C1)CC2=C(C(=O)NC(=O)N2)Cl

Tipiracil is a thymidine phosphorylase inhibitor primarily used as a component of the combination drug trifluridine/tipiracil for treating metastatic colorectal cancer. By preventing the degradation of trifluridine, Tipiracil enhances the antitumor activity of this cytotoxic nucleoside analog. It also exhibits antiangiogenic properties by reducing thymidine phosphorylase-mediated angiogenesis, contributing to its therapeutic potential. Tipiracil is extensively studied for its role in cancer metabolism and resistance mechanisms, making it a crucial compound in oncology and chemotherapy research.