TIQ-A

• CAT Number: R004510
• CAS Number: 420849-22-5
• Molecular Formula: C11H7NOS
• Molecular Weight: 201.243
• Purity: ≥95%
• Synonyms: Thieno[2,3-C]isoquinolin-5-one
• Target: Epigenetics
• Storage: -20°C
• IUPAC Name: 4H-thieno[2,3-c]isoquinolin-5-one
• InChI: InChI=1S/C11H7NOS/c13-10-8-4-2-1-3-7(8)9-5-6-14-11(9)12-10/h1-6H,(H,12,13)
• InChIKey: LQJVOLSLAFIXSV-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)C3=C(NC2=O)SC=C3

Poly(ADP-<wbr></wbr>ribose) polymerase 1 (PARP1) is a critical DNA repair enzyme involved in DNA single-<wbr></wbr>strand break repair via the base excision repair pathway. PARP1 is triggered by DNA damage and its excessive activation has been proposed as a causative factor in many pathological conditions including ischemia and reperfusion injury, asthma-<wbr></wbr>related inflammation, and atherogenesis. TIQ-<wbr></wbr>A is a PARP1 inhibitor (IC50 = 450 nM in cultured mouse cortical neurons). It displays neuroprotective effects in cultured mouse cortical neurons injured by oxygen-<wbr></wbr>glucose deprivation (IC50 = 0.15 µM). TIQ-<wbr></wbr>A has been used to inhibit eosinophilic infiltration into airways of OVA-<wbr></wbr>challenged mice and to induce the regression of atherosclerotic plaques in high-<wbr></wbr>fat fed apolipoprotein E(-/-) mice.