Tirapazamine

• CAT Number: I002938
• CAS Number: 27314-97-2
• Molecular Formula: C7H6N4O2
• Molecular Weight: 178.15
• Purity: ≥95%
• Synonyms: Tirapazamine; Tirazone; SR 4233; SR-4233; SR4233; SR259075; SR-259075; SR 259075; WIN 59075; NSC130181
• Target: DNA/RNA Synthesis
• Solubility: DMSO: ≥ 39 mg/mL
• Storage: -20°C
• IUPAC Name: 1,4-dioxido-1,2,4-benzotriazine-1,4-diium-3-amine
• InChI: InChI=1S/C7H6N4O2/c8-7-9-11(13)6-4-2-1-3-5(6)10(7)12/h1-4H,(H2,8,9)
• InChIKey: ORYDPOVDJJZGHQ-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)[N+](=C(N=[N+]2[O-])N)[O-]

Tirapazamine（Cat No.:I002938）is a hypoxia-activated prodrug designed to target and kill cancer cells in low-oxygen (hypoxic) environments, which are common in solid tumors. Under hypoxic conditions, Tirapazamine is converted into a toxic radical that induces DNA damage, leading to selective cancer cell death. This mechanism enhances the efficacy of conventional radiotherapy and chemotherapy, as hypoxic tumor cells are often resistant to these treatments. Tirapazamine’s ability to exploit tumor hypoxia makes it a promising agent in oncology, potentially improving treatment outcomes for patients with aggressive and hard-to-treat cancers.