For research use only. Not for therapeutic Use.
Tiron is a non-toxic chelator of a variety of metals. Tiron is cell permeable analog of vitamin E and function as
hydroxyl radical and superoxide scavenger. Tiron is an orally active antioxidant. Tiron can be used to alleviate acute metal overload in animals[1][2][3].
Tiron (10 mM) protects Chinese hamster V79 cells against H2O2-induced cytotoxicity[1].
Tiron (0-20 mM) protects supercoiled DNA from metal-mediated superoxide-dependent strand breaks[1].
Tiron (50 nM-200 nM, 48 h) inhibits HG-induced neonatal rat cardiomyocytes apoptosis[3].
Tiron (50 nM-200 nM, 48 h) reduces intracellular osteopontin in neonatal rat cardiomyocytes[3].
Tiron (0.2 mM, 2 h) inhibits UVB-induced up-regulation of MMP-1 and MMP-3 in HDFs[4].
Tiron (0.7 mM, 48 h) increases the percentage of PT4 cells in both the S and G2/M phases[5].
Tiron (200 mg/kg, oral gavage) ameliorates oxidative stress and inflammation in a murine model of airway remodeling[2].
Tiron (300 mg/kg, i.p., daily for two weeks) alleviated apoptosis of the left ventricular cardiomyocytes in STZ-induced diabetic mice[3].
| Catalog Number | M067100 |
| CAS Number | 149-45-1 |
| Synonyms | disodium;4,5-dihydroxybenzene-1,3-disulfonate |
| Molecular Formula | C6H4Na2O8S2 |
| Purity | ≥95% |
| InChI | InChI=1S/C6H6O8S2.2Na/c7-4-1-3(15(9,10)11)2-5(6(4)8)16(12,13)14;;/h1-2,7-8H,(H,9,10,11)(H,12,13,14);;/q;2*+1/p-2 |
| InChIKey | ISWQCIVKKSOKNN-UHFFFAOYSA-L |
| SMILES | C1=C(C=C(C(=C1O)O)S(=O)(=O)[O-])S(=O)(=O)[O-].[Na+].[Na+] |
| Reference | [1]. Krishna CM, et al. The catecholic metal sequestering agent 1,2-dihydroxybenzene-3,5-disulfonate confers protection against oxidative cell damage. Arch Biochem Biophys. 1992 Apr;294(1):98-106. 2. [2]. El-Sherbeeny NA, et al. Tiron ameliorates oxidative stress and inflammation in a murine model of airway remodeling. Int Immunopharmacol. 2016 Oct;39:172-180. [3]. Jiang P, et al. Tiron ameliorates high glucose-induced cardiac myocyte apoptosis by PKCδ-dependent inhibition of osteopontin. Clin Exp Pharmacol Physiol. 2017 Jul;44(7):760-770. [4]. Lu J, et al. Tiron Inhibits UVB-Induced AP-1 Binding Sites Transcriptional Activation on MMP-1 and MMP-3 Promoters by MAPK Signaling Pathway in Human Dermal Fibroblasts. PLoS One. 2016 Aug 3;11(8):e0159998. [5]. Monticone M, et al. NAC, tiron and trolox impair survival of cell cultures containing glioblastoma tumorigenic initiating cells by inhibition of cell cycle progression. PLoS One. 2014 Feb 28;9(2):e90085. |
