Tivanisiran sodium

• CAT Number: I040023
• CAS Number: 1848239-71-3
• Molecular Formula: C361H411N141O262Na36P36
• Molecular Weight: 12859.67
• Purity: ≥95%

Tivanisiran Sodium (Cat No.: I040023) is a small interfering RNA (siRNA) designed to target and silence human transient receptor potential cation channel subfamily V member 1 (TRPV1), a key mediator of ocular pain and inflammation. It is primarily investigated for the treatment of dry eye disease and other ocular surface disorders. By inhibiting TRPV1 expression, Tivanisiran reduces inflammation and neuropathic pain, offering a novel therapeutic approach. The sodium salt form enhances solubility and stability for in vitro and clinical applications in ophthalmology.

Reference

[1]. Anne-Marie Bleau, et al. Development of tivanisiran, a topical siRNA designed to

[2]. Javier Moreno-Montañés, et al. Tivanisiran, a novel siRNA for the treatment of dry eye disease. Expert Opin Investig Drugs. 2018 Apr;27(4):421-426.
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