For research use only. Not for therapeutic Use.
Tizoxanide（Cat No.:I002266）is an active metabolite of tizoxanide, a broad-spectrum antiparasitic agent used primarily for the treatment of gastrointestinal infections caused by Entamoeba histolytica, Giardia lamblia, and Cryptosporidium parvum. It works by inhibiting the anaerobic energy metabolism of protozoa, leading to their death. Tizoxanide is also effective against certain bacterial infections. It is commonly used in the treatment of conditions like amoebiasis and giardiasis. As an oral medication, tizoxanide demonstrates favorable pharmacokinetics and has minimal side effects, making it a reliable option in parasitic infection management.
| Catalog Number | I002266 |
| CAS Number | 173903-47-4 |
| Synonyms | 2-hydroxy-N-(5-nitrothiazol-2-yl)benzamide |
| Molecular Formula | C10H7N3O4S |
| Purity | ≥95% |
| Target | Autophagy |
| Solubility | DMSO: ≥ 38 mg/mL |
| Storage | Store at -20°C |
| IUPAC Name | 2-hydroxy-N-(5-nitro-1,3-thiazol-2-yl)benzamide |
| InChI | InChI=1S/C10H7N3O4S/c14-7-4-2-1-3-6(7)9(15)12-10-11-5-8(18-10)13(16)17/h1-5,14H,(H,11,12,15) |
| InChIKey | FDTZUTSGGSRHQF-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C(=C1)C(=O)NC2=NC=C(S2)[N+](=O)[O-])O |
| Reference | </br>1:Activity of nitazoxanide and tizoxanide against Mycobacterium tuberculosis in vitro and in whole blood culture. Harausz EP, Chervenak KA, Good CE, Jacobs MR, Wallis RS, Sanchez-Felix M, Boom WH; TB Research Unit (TBRU) at Case Western Reserve University..Tuberculosis (Edinb). 2016 May;98:92-6. doi: 10.1016/j.tube.2016.03.002. Epub 2016 Mar 22. PMID: 27156623 Free PMC Article</br>2:Simultaneous quantification of tizoxanide and tizoxanide glucuronide in mouse plasma by liquid chromatography-tandem mass spectrometry. Liu J, Meng F, Li Z, Yu L, Peng S, Guo J, Xu H.Biomed Chromatogr. 2016 Nov;30(11):1744-1749. doi: 10.1002/bmc.3748. Epub 2016 May 17. PMID: 27105783 </br>3:Tizoxanide pyridine monosolvate. Zheng H, Deng H, Chen Y, Li D.Acta Crystallogr Sect E Struct Rep Online. 2012 May 1;68(Pt 5):o1453-4. doi: 10.1107/S1600536812016133. Epub 2012 Apr 21. PMID: 22590331 Free PMC Article</br>4:Development of a method by UPLC-MS/MS for the quantification of tizoxanide in human plasma and its pharmacokinetic application. Marcelín-Jiménez G, Contreras-Zavala L, Maggi-Castellanos M, Angeles-Moreno AP, García-González A.Bioanalysis. 2012 May;4(8):909-17. doi: 10.4155/bio.12.41. PMID: 22533565 </br>5:Validated and optimized high-performance liquid chromatographic determination of tizoxanide, the main active metabolite of nitazoxanide in human urine, plasma and breast milk. Hadad GM, Abdel Salam RA, Emara S.J Chromatogr Sci. 2012 Jul;50(6):509-15. doi: 10.1093/chromsci/bms041. Epub 2012 Apr 23. PMID: 22525879 </br>6:Synthesis of benzologues of Nitazoxanide and Tizoxanide: a comparative study of their in vitro broad-spectrum antiprotozoal activity. Navarrete-Vazquez G, Chávez-Silva F, Argotte-Ramos R, Rodríguez-Gutiérrez Mdel C, Chan-Bacab MJ, Cedillo-Rivera R, Moo-Puc R, Hernández-Nuñez E.Bioorg Med Chem Lett. 2011 May 15;21(10):3168-71. doi: 10.1016/j.bmcl.2011.02.100. Epub 2011 Feb 26. PMID: 21397502 </br>7:In Vitro Susceptibility of Canine Influenza A (H3N8) Virus to Nitazoxanide and Tizoxanide. Ashton LV, Callan RL, Rao S, Landolt GA.Vet Med Int. 2010 Aug 12;2010. pii: 891010. doi: 10.4061/2010/891010. PMID: 20847948 Free PMC Article</br>8:The pharmacokinetics of nitazoxanide active metabolite (tizoxanide) in goats and its protein binding ability in vitro. Zhao Z, Xue F, Zhang L, Zhang K, Fei C, Zheng W, Wang X, Wang M, Zhao Z, Meng X.J Vet Pharmacol Ther. 2010 Apr;33(2):147-53. doi: 10.1111/j.1365-2885.2009.01119.x. PMID: 20444039 </br>9:Nitazoxanide, tizoxanide and a new analogue [4-nitro-N-(5-nitro-1,3-thiazol-2-yl)benzamide; NTB] inhibit the growth of kinetoplastid parasites (Trypanosoma cruzi and Leishmania mexicana) in vitro. Chan-Bacab MJ, Hernández-Núñez E, Navarrete-Vázquez G.J Antimicrob Chemother. 2009 Jun;63(6):1292-3. doi: 10.1093/jac/dkp117. Epub 2009 Apr 4. No abstract available. PMID: 19346519 </br>10:Brugia malayi: Effects of nitazoxanide and tizoxanide on adult worms and microfilariae of filarial nematodes. Rao RU, Huang Y, Fischer K, Fischer PU, Weil GJ.Exp Parasitol. 2009 Jan;121(1):38-45. doi: 10.1016/j.exppara.2008.09.020. Epub 2008 Oct 17. PMID: 18977224 |
