For research use only. Not for therapeutic Use.
TKIM is a TREK-1 channel inhibitor with an IC50 of 2.96 μM. TKIM binds to the pocket of the intermediate (IM) state of TREK-1[1].
| Catalog Number | I037340 |
| CAS Number | 326921-25-9 |
| Synonyms | 4-chloro-N’-(2-quinolin-2-ylsulfanylacetyl)benzohydrazide |
| Molecular Formula | C18H14ClN3O2S |
| Purity | ≥95% |
| InChI | InChI=1S/C18H14ClN3O2S/c19-14-8-5-13(6-9-14)18(24)22-21-16(23)11-25-17-10-7-12-3-1-2-4-15(12)20-17/h1-10H,11H2,(H,21,23)(H,22,24) |
| InChIKey | BWTKIGGLLXUFSV-UHFFFAOYSA-N |
| SMILES | C1=CC=C2C(=C1)C=CC(=N2)SCC(=O)NNC(=O)C3=CC=C(C=C3)Cl |
| Reference | [1]. Yuqin Ma, et al. Discovery of an Inhibitor for the TREK-1 Channel Targeting an Intermediate Transition State of Channel Gating. J Med Chem. 2020 Oct 8;63(19):10972-10983. |
