TKN87180

• CAT Number: I037341
• CAS Number: 756487-18-0
• Molecular Formula: C37H49N5O8
• Molecular Weight: 691.83
• Purity: 98%
• Synonyms: TKN87180; TKN-87180; TKN 87180
• Target: ADC Linker
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: tert-butyl ((S)-5-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-phenylpropanamido)-6-((4-(hydroxymethyl)phenyl)amino)-6-oxohexyl)carbamate
• InChI: InChI=1S/C37H49N5O8/c1-37(2,3)50-36(49)38-22-10-9-14-29(34(47)39-28-18-16-27(25-43)17-19-28)41-35(48)30(24-26-12-6-4-7-13-26)40-31(44)15-8-5-11-23-42-32(45)20-21-33(42)46/h4,6-7,12-13,16-21,29-30,43H,5,8-11,14-15,22-25H2,1-3H3,(H,38,49)(H,39,47)(H,40,44)(H,41,48)/t29-,30-/m0/s1
• InChIKey: TUPIPBYBJMCLLM-KYJUHHDHSA-N
• SMILES: O=C([C@@H](NC([C@@H](NC(CCCCCN1C(C=CC1=O)=O)=O)CC2=CC=CC=C2)=O)CCCCNC(OC(C)(C)C)=O)NC3=CC=C(C=C3)CO

TKN87180(CAT: I037341) is a hydrolyzable linker designed for use in the synthesis of antibody-drug conjugates (ADCs). This linker facilitates the stable attachment of cytotoxic payloads to monoclonal antibodies, ensuring selective delivery to target cells. Its hydrolyzable property allows for precise payload release in the intracellular environment, enhancing therapeutic efficacy while minimizing off-target effects. TKN87180 is particularly relevant in the field of antibody-drug conjugate development, supporting advanced research into targeted cancer therapies. With its high stability and reliable performance, TKN87180 is an essential component in ADC research and the development of next-generation precision therapeutics.