TL02-59

• CAT Number: I018179
• CAS Number: 1315330-17-6
• Molecular Formula: C₃₂H₃₄F₃N₅O₄
• Molecular Weight: 609.64
• Purity: ≥95%
• IUPAC Name: 3-(6,7-dimethoxyquinazolin-4-yl)oxy-N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methylbenzamide
• InChI: InChI=1S/C32H34F3N5O4/c1-5-39-10-12-40(13-11-39)18-22-8-9-23(15-25(22)32(33,34)35)38-30(41)21-7-6-20(2)27(14-21)44-31-24-16-28(42-3)29(43-4)17-26(24)36-19-37-31/h6-9,14-17,19H,5,10-13,18H2,1-4H3,(H,38,41)
• InChIKey: AMHWQBGAKJESFB-UHFFFAOYSA-N
• SMILES: CCN1CCN(CC1)CC2=C(C=C(C=C2)NC(=O)C3=CC(=C(C=C3)C)OC4=NC=NC5=CC(=C(C=C54)OC)OC)C(F)(F)F

TL02-59（Cat No.:I018179）is a selective inhibitor of the sirtuin family of NAD+-dependent deacetylases, specifically targeting SIRT2. Sirtuins play a critical role in regulating cellular processes such as metabolism, aging, and stress responses. By inhibiting SIRT2, TL02-59 has shown potential in neurodegenerative disease research, particularly in studies related to Parkinson’s and Huntington’s diseases, where abnormal SIRT2 activity is implicated. Additionally, TL02-59 is valuable in cancer research, where it helps explore the role of sirtuins in tumorigenesis and cellular senescence, making it a promising candidate for therapeutic development.

Reference

[1]. Weir MC, et al. Selective Inhibition of the Myeloid Src-Family Kinase Fgr Potently Suppresses AML Cell Growth in Vitro and in Vivo. ACS Chem Biol. 2018 Jun 15;13(6):1551-1559.