For research use only. Not for therapeutic Use.
TL12-186 (Cat.No:I014787) is a CRBN-dependent multi-kinase PROTAC degrader. Multi-kinases include CDK, BTK, FLT3, Aurora kinases, TEC, ULK, ITK, et al. TL12-186 inhibits CDK2/cyclin A (IC50=73 nM) and CDK9/cyclin T1 (IC50=55 nM).
| Catalog Number | I014787 |
| CAS Number | 2250025-88-6 |
| Molecular Formula | C₄₄H₅₁ClN₁₀O₉S |
| Purity | ≥95% |
| Reference | [1]. Hai-Tsang Huang, et al. A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader. Cell Chem Biol. 2018 Jan 18;25(1):88-99.e6. |
