For research use only. Not for therapeutic Use.
TL8-506 is a specific TLR8 agonist with an EC50 of 30 nM. TL8-506 can be used for the research of tuberculosis and autoimmune diseases[1].
| Catalog Number | I043822 |
| CAS Number | 1268163-15-0 |
| Synonyms | ethyl 2-amino-8-(3-cyanophenyl)-3H-1-benzazepine-4-carboxylate |
| Molecular Formula | C20H17N3O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C20H17N3O2/c1-2-25-20(24)17-9-16-7-6-15(10-18(16)23-19(22)11-17)14-5-3-4-13(8-14)12-21/h3-10H,2,11H2,1H3,(H2,22,23) |
| InChIKey | YHRYTTWRVKXODS-UHFFFAOYSA-N |
| SMILES | CCOC(=O)C1=CC2=C(C=C(C=C2)C3=CC=CC(=C3)C#N)N=C(C1)N |
| Reference | [1]. Jun Tang, et al. Toll-Like Receptor 8 Agonist Strengthens the Protective Efficacy of ESAT-6 Immunization to Mycobacterium tuberculosis Infection. Front Immunol. 2018 Jan 24;8:1972. |
