For research use only. Not for therapeutic Use.
TLR7 agonist 1 is a potent, selective and oral TLR7 agonist with an IC50 of 90 nM.
| Catalog Number | I019536 |
| CAS Number | 2178156-33-5 |
| Synonyms | 2-amino-4-(butylamino)-N-[(1S)-1-phenylethyl]quinazoline-5-carboxamide |
| Molecular Formula | C21H25N5O |
| Purity | ≥95% |
| InChI | InChI=1S/C21H25N5O/c1-3-4-13-23-19-18-16(11-8-12-17(18)25-21(22)26-19)20(27)24-14(2)15-9-6-5-7-10-15/h5-12,14H,3-4,13H2,1-2H3,(H,24,27)(H3,22,23,25,26)/t14-/m0/s1 |
| InChIKey | WDFAZLUMAXOURM-AWEZNQCLSA-N |
| SMILES | CCCCNC1=NC(=NC2=CC=CC(=C21)C(=O)NC(C)C3=CC=CC=C3)N |
| Reference | [1]. Pieters S, et al. Discovery of selective 2,4-diaminoquinazoline toll-like receptor 7 (TLR 7) agonists. Bioorg Med Chem Lett. 2018 Feb 15;28(4):711-719. |
