TLR9-IN-1

• CAT Number: I042910
• CAS Number: 2226366-86-3
• Molecular Formula: C23H31N7O
• Molecular Weight: 421.54
• Purity: ≥95%
• Synonyms: N-[3-(dimethylamino)propyl]-1-[2-(4-methylphenyl)pyrazolo[3,4-d]pyridazin-7-yl]piperidine-4-carboxamide
• InChI: InChI=1S/C23H31N7O/c1-17-5-7-20(8-6-17)30-16-19-15-25-26-22(21(19)27-30)29-13-9-18(10-14-29)23(31)24-11-4-12-28(2)3/h5-8,15-16,18H,4,9-14H2,1-3H3,(H,24,31)
• InChIKey: FRMXKWKQIYLSMO-UHFFFAOYSA-N
• SMILES: CC1=CC=C(C=C1)N2C=C3C=NN=C(C3=N2)N4CCC(CC4)C(=O)NCCCN(C)C

TLR9-IN-1（Cat No.:I042910）is a selective inhibitor targeting Toll-like receptor 9 (TLR9), a crucial component of the innate immune system that recognizes pathogen-associated DNA. TLR9 plays a role in initiating immune responses by detecting unmethylated CpG motifs commonly found in bacterial and viral DNA. By inhibiting TLR9, TLR9-IN-1 modulates immune responses, which can be beneficial in treating autoimmune diseases where TLR9 is abnormally activated, such as lupus or rheumatoid arthritis. Additionally, this compound is being explored for its potential in cancer therapy, as it may help to balance immune activation in the tumor microenvironment.