TM-5275 Sodium salt

• CAT Number: I009632
• CAS Number: 1103926-82-4
• Molecular Formula: C28H27ClN3NaO5
• Molecular Weight: 543.98
• Purity: ≥95%
• Synonyms: TM5275 sodium salt; TM-5275 sodium salt; TM 5275 sodium salt.;5-Chloro-2-[[2-[2-[4-(Diphenylmethyl)-1-piperazinyl]-2-oxoethoxy]acetyl]amino]benzoic acid sodium salt
• Target: PAI-1
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: sodium;2-[[2-[2-(4-benzhydrylpiperazin-1-yl)-2-oxoethoxy]acetyl]amino]-5-chlorobenzoate
• InChI: InChI=1S/C28H28ClN3O5.Na/c29-22-11-12-24(23(17-22)28(35)36)30-25(33)18-37-19-26(34)31-13-15-32(16-14-31)27(20-7-3-1-4-8-20)21-9-5-2-6-10-21;/h1-12,17,27H,13-16,18-19H2,(H,30,33)(H,35,36);/q;+1/p-1
• InChIKey: JSHSGBIWNPQCQZ-UHFFFAOYSA-M
• SMILES: C1CN(CCN1C(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)COCC(=O)NC4=C(C=C(C=C4)Cl)C(=O)[O-].[Na+]

TM-5275 sodium salt(CAT: I009632), an orally bioavailable compound, functions as a potent inhibitor of plasminogen activator inhibitor-1 (PAI-1). PAI-1 plays a crucial role in regulating fibrinolysis, and its dysregulation is associated with various pathological conditions. By targeting PAI-1, TM-5275 sodium salt has the potential to modulate fibrinolysis and contribute to therapeutic interventions in conditions characterized by altered coagulation and fibrin clot dissolution. This inhibitor holds promise as a pharmacological tool to influence PAI-1 activity and may have implications in the treatment of disorders linked to fibrinolysis and clotting cascades.