TM-5441

• CAT Number: I012016
• CAS Number: 1190221-43-2
• Molecular Formula: C21H17ClN2O6
• Molecular Weight: 428.82
• Purity: ≥95%
• Synonyms: TM-5441; TM 5441; TM5441; BMS-790052; BMS-790052; BMS790052; EBP 883; EBP-883; EBP883.;5-chloro-2-(2-(2-((3-(furan-3-yl)phenyl)amino)-2-oxoethoxy)acetamido)benzoic acid
• Solubility: Soluble in DMSO
• Storage: Store at 0-8 °C
• IUPAC Name: 5-chloro-2-[[2-[2-[3-(furan-3-yl)anilino]-2-oxoethoxy]acetyl]amino]benzoic acid
• InChI: InChI=1S/C21H17ClN2O6/c22-15-4-5-18(17(9-15)21(27)28)24-20(26)12-30-11-19(25)23-16-3-1-2-13(8-16)14-6-7-29-10-14/h1-10H,11-12H2,(H,23,25)(H,24,26)(H,27,28)
• InChIKey: BGGMLMAPVODXAU-UHFFFAOYSA-N
• SMILES: C1=CC(=CC(=C1)NC(=O)COCC(=O)NC2=C(C=C(C=C2)Cl)C(=O)O)C3=COC=C3

TM-5441（Cat No.:I012016）is a selective inhibitor of plasminogen activator inhibitor-1 (PAI-1), a protein involved in regulating fibrinolysis and thrombotic processes. By inhibiting PAI-1, TM-5441 enhances fibrinolytic activity, making it a valuable compound in cardiovascular and metabolic disease research, especially concerning thrombosis and atherosclerosis. Studies suggest TM-5441 may have protective effects against aging-related diseases and fibrosis by modulating cellular senescence and inflammation. Its applications extend to potential therapeutic exploration for conditions involving vascular health, fibrosis, and metabolic disorders, contributing insights into PAI-1’s role in disease mechanisms.

Reference

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