TMC-169

• CAT Number: I037362
• CAS Number: 242147-94-0
• Molecular Formula: C24H35NO3
• Molecular Weight: 385.55
• Purity: 98%
• Synonyms: J1.138.912K; TMC-169; TMC 169; TMC169
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (1S,3E,9E,11S,14S,15R,16S)-5-hydroxy-9,13,14-trimethyl-16-(2-methylpropyl)-17-azatricyclo[9.7.0.01,15]octadeca-3,9,12-triene-2,18-dione
• InChI: 1S/C24H35NO3/c1-14(2)11-20-22-17(5)16(4)13-18-12-15(3)7-6-8-19(26)9-10-21(27)24(18,22)23(28)25-20/h9-10,12-14,17-20,22,26H,6-8,11H2,1-5H3,(H,25,28)/b10-9+,15-12+/t17-,18+,19?,20+,22+,24-/m1/s1
• InChIKey: PBMWGTZJDVBFGK-YJEZAUDRSA-N
• SMILES: CC(C)C[C@@H]1NC(=O)[C@@]23[C@H](C=C(C)[C@@H](C)[C@@H]12)C=C(/C)CCCC(O)C=CC3=O

TMC-169(CAT: I037362) is an antibiotic belonging to the echinocandin class, known for its potent antifungal activity. It functions by inhibiting β-1,3-D-glucan synthase, an essential enzyme for fungal cell wall synthesis. This inhibition disrupts the structural integrity of the fungal cell wall, leading to cell lysis and death. TMC-169 is particularly effective against Candida and Aspergillus species, making it a valuable candidate in the treatment of invasive fungal infections. Its targeted mechanism offers high selectivity for fungal pathogens with minimal toxicity to human cells, supporting its role in anti-infective research and antifungal drug development.