For research use only. Not for therapeutic Use.
TMDJ-035 is a selective RyR2 inhibitor. TMDJ-035 suppresses abnormal Ca2+ waves and transients in isolated cardiomyocytes from RyR2-mutated mice. TMDJ-035is a tool for studying the mechanism and dynamics of RyR2 channel gating[1].
| Catalog Number | I040607 |
| CAS Number | 2681302-83-8 |
| Synonyms | 2-[5-(3,5-difluorophenyl)tetrazol-2-yl]-N-(4-fluorophenyl)-N-methylacetamide |
| Molecular Formula | C16H12F3N5O |
| Purity | ≥95% |
| InChI | InChI=1S/C16H12F3N5O/c1-23(14-4-2-11(17)3-5-14)15(25)9-24-21-16(20-22-24)10-6-12(18)8-13(19)7-10/h2-8H,9H2,1H3 |
| InChIKey | IRUXEBHABFUBKY-UHFFFAOYSA-N |
| SMILES | CN(C1=CC=C(C=C1)F)C(=O)CN2N=C(N=N2)C3=CC(=CC(=C3)F)F |
| Reference | [1]. Ryosuke Ishida, et al. A potent and selective cis-amide inhibitor of ryanodine receptor 2 as a candidate for cardiac arrhythmia treatment. European Journal of Medicinal Chemistry |
