TMI 1

• CAT Number: I011346
• CAS Number: 287403-39-8
• Molecular Formula: C17H22N2O5S2
• Molecular Weight: 398.49
• Purity: ≥95%
• Synonyms: (3S)-4-[[4-(2-Butyn-1-yloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-3-thiomorpholinecarboxamide
• Solubility: Soluble to 100 mM in DMSO and to 20 mM in ethanol
• Storage: Store at -20C
• IUPAC Name: (3S)-4-(4-but-2-ynoxyphenyl)sulfonyl-N-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide
• InChI: InChI=1S/C17H22N2O5S2/c1-4-5-11-24-13-6-8-14(9-7-13)26(22,23)19-10-12-25-17(2,3)15(19)16(20)18-21/h6-9,15,21H,10-12H2,1-3H3,(H,18,20)/t15-/m0/s1
• InChIKey: CVZIHNYAZLXRRS-HNNXBMFYSA-N
• SMILES: CC#CCOC1=CC=C(C=C1)S(=O)(=O)N2CCSC([C@@H]2C(=O)NO)(C)C

TMI 1（Cat No.:I011346）is a potent and selective inhibitor of tumor necrosis factor-alpha converting enzyme (TACE), also known as ADAM17. This enzyme is essential in the shedding of TNF-α and other cell surface proteins, making TMI 1 a valuable tool in inflammatory and cancer research. By blocking TACE activity, TMI 1 reduces TNF-α release, offering insights into therapeutic approaches for inflammatory diseases like rheumatoid arthritis and certain cancers. Its specificity and efficacy make TMI 1 ideal for investigating pathways related to inflammation and tumor progression, aiding drug discovery efforts.