For research use only. Not for therapeutic Use.
TMP920 is a highly potent and selective RORγt antagonist. TMP920 inhibits RORγt binding to the SRC1 peptide with an IC50 of 0.03 μM[1].
TMP920 (0.09-30 μM) starts to show toxic effects on cell growth at >10 μM in Naïve CD4+ T cells[1].
TMP920 suppresses Th17 cell differentiation and lost its IL-17 inhibitory effect at <2.5 μM in vitro[1].
TMP920 suppresses IL-17 production from differentiated Th17 cells in vitro[1].
TMP920 suppresses the Th17 cell transcriptome and promotes alternate T-cell subsets[1].
TMP920 significantly reduces RORγt-DNA interactions[1].
| Catalog Number | I017430 |
| CAS Number | 1421837-45-7 |
| Synonyms | 2-[4-[(3,5-dimethyl-1,2-oxazol-4-yl)methoxy]phenyl]-N-[(2,4-dimethylphenyl)-phenylmethyl]acetamide |
| Molecular Formula | C29H30N2O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C29H30N2O3/c1-19-10-15-26(20(2)16-19)29(24-8-6-5-7-9-24)30-28(32)17-23-11-13-25(14-12-23)33-18-27-21(3)31-34-22(27)4/h5-16,29H,17-18H2,1-4H3,(H,30,32) |
| InChIKey | SHMBIDOWYJZWLB-UHFFFAOYSA-N |
| SMILES | CC1=CC(=C(C=C1)C(C2=CC=CC=C2)NC(=O)CC3=CC=C(C=C3)OCC4=C(ON=C4C)C)C |
| Reference | [1]. Xiao S, et al. Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms. Immunity. 2014 Apr 17;40(4):477-89. |
