For research use only. Not for therapeutic Use.
TMX-4100 is a selective phosphodiesterase 6D (PDE6D) degrader. TMX-4100 shows a high degradation preference for PDE6D with the DC50 values less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4100 can be used for the research of multiple myeloma[1].
TMX-4100 (compound 3; 1 μM; 4 h) shows a high degradation preference for PDE6D in MOLT4 cells[1].
TMX-4100 has better proteome-wide degradation selectivity in MOLT4 cells, compare to PDE6D degrader FPFT-2216[1].
TMX-4100 does not impede the growth of KRAS-dependent cell lines (MIA PaCa-2, NCI-H358, AGS, PA-TU-8988T cells)[1].
| Catalog Number | I045150 |
| CAS Number | 2367619-63-2 |
| Synonyms | 3-(4-thiophen-3-yltriazol-1-yl)piperidine-2,6-dione |
| Molecular Formula | C11H10N4O2S |
| Purity | ≥95% |
| InChI | InChI=1S/C11H10N4O2S/c16-10-2-1-9(11(17)12-10)15-5-8(13-14-15)7-3-4-18-6-7/h3-6,9H,1-2H2,(H,12,16,17) |
| InChIKey | PGEUBQZQGXWTFO-UHFFFAOYSA-N |
| SMILES | C1CC(=O)NC(=O)C1N2C=C(N=N2)C3=CSC=C3 |
| Reference | [1]. Teng M, et al. Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216. J Med Chem. 2022 Jan 13;65(1):747-756. |
