For research use only. Not for therapeutic Use.
TMX-4113 is a degrader of phosphodiesterase 6D (PDE6D) and casein kinase 1α (CK1α). TMX-4113 can be used for the research of cancer[1].
TMX-4113 (compound 21; 1 μM; 4 h) shows a high degradation preference for PDE6D and CK1α in MOLT4 cells[1].
TMX-4113 (0 nM, 40 nM, 200 nM, 1µM; 4h) induces degradation of PDE6D in MOLT4 cells[1].
TMX-4113 (0 nM, 40 nM, 200 nM, 1µM; 4h) degrades over 50% of CK1α at a dose of 40 nM in MM.1S cells[1].
| Catalog Number | I045151 |
| CAS Number | 2766385-92-4 |
| Synonyms | 3-[4-(4-methylsulfanylthiophen-3-yl)triazol-1-yl]piperidine-2,6-dione |
| Molecular Formula | C12H12N4O2S2 |
| Purity | ≥95% |
| InChI | InChI=1S/C12H12N4O2S2/c1-19-10-6-20-5-7(10)8-4-16(15-14-8)9-2-3-11(17)13-12(9)18/h4-6,9H,2-3H2,1H3,(H,13,17,18) |
| InChIKey | YIIUEHDPOPLUBR-UHFFFAOYSA-N |
| SMILES | CSC1=CSC=C1C2=CN(N=N2)C3CCC(=O)NC3=O |
| Reference | [1]. Teng M, et al. Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216. J Med Chem. 2022 Jan 13;65(1):747-756. |
