TNF-α (31-45), human

• CAT Number: M099606
• CAS Number: 144796-71-4
• Molecular Formula: C69H122N26O22
• Molecular Weight: 1667.87
• Purity: ≥95%

TNF-α (31-45), human is a potent NF-kB pathway activator. TNF-αis a proinflammatory cytokine that induces necrosis or apoptosis. TNF alpha stimulates NF-κB pathway via TNFR2 promotes cancer growth, invasion, and metastasis[1][2][3].
TNF-α (31-45), human (5 μM; for 1 h) promotes cisplatin resistance by the activation of the NF-kB pathway. TNF-α (31-45), human does not alter RPS3 expression levels[2].

Reference

[1]. Idriss HT, Naismith JH. TNF alpha and the TNF receptor superfamily: structure-function relationship(s). Microsc Res Tech. 2000 Aug 1;50(3):184-95.
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[2]. Xi Rui, et al. RPS3 Promotes the Metastasis and Cisplatin Resistance of Adenoid Cystic Carcinoma. Front Oncol. 2022 Jun 30:12:804439.
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[3]. Jang DI, et al. The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics. Int J Mol Sci. 2021 Mar 8;22(5):2719.
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