TNF-α-IN-1

• CAT Number: I020071
• CAS Number: 444287-49-4
• Molecular Formula: C₁₆H₁₄ClN₃O₅
• Molecular Weight: 363.75
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: 2-chloro-N-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]methyl]acetamide
• InChI: InChI=1S/C16H14ClN3O5/c17-6-12(22)18-7-8-2-1-3-9-13(8)16(25)20(15(9)24)10-4-5-11(21)19-14(10)23/h1-3,10H,4-7H2,(H,18,22)(H,19,21,23)
• InChIKey: XRAYWKDMFVKUTJ-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=CC=CC(=C3C2=O)CNC(=O)CCl

TNF-α-IN-1 (Cat No.:I020071) is an inhibitor of tumor necrosis factor-alpha (TNF-α), a cytokine involved in inflammation and immune system regulation. TNF-α-IN-1 inhibits the binding of TNF-α to its receptor and downstream signaling, resulting in reduced inflammation and potential therapeutic benefits. It is effective in animal models of inflammatory bowel disease and rheumatoid arthritis. TNF-α-IN-1 also has the potential for the treatment of other inflammatory and autoimmune diseases.

Reference

[1]. Robarge M, et al. Isoindole-imide compounds, compositions, and uses thereof. US20030096841A1