For research use only. Not for therapeutic Use.
TNG-462 (Cat No.: I040766) is a selective, small-molecule inhibitor designed to target methylthioadenosine phosphorylase (MTAP)-deleted cancers by exploiting vulnerabilities in tumors lacking MTAP. It functions through PRMT5 (protein arginine methyltransferase 5) inhibition, particularly in MTAP-deficient cells where PRMT5 becomes synthetically essential. TNG-462 exhibits potent and selective anti-tumor activity by impairing PRMT5-mediated epigenetic regulation. It is used in preclinical research to investigate targeted cancer therapies leveraging synthetic lethality, offering a promising therapeutic strategy for genetically defined cancers with MTAP deletions.
| CAS Number | 2760483-96-1 |
| Synonyms | N-(6-amino-5-ethylpyridin-3-yl)-2-[(2R,5S)-5-methyl-2-[2-(1-methylpiperidin-4-yl)-1,3-benzothiazol-5-yl]piperidin-1-yl]-2-oxoacetamide |
| Molecular Formula | C28H36N6O2S |
| Purity | ≥95% |
| InChI | InChI=1S/C28H36N6O2S/c1-4-18-13-21(15-30-25(18)29)31-26(35)28(36)34-16-17(2)5-7-23(34)20-6-8-24-22(14-20)32-27(37-24)19-9-11-33(3)12-10-19/h6,8,13-15,17,19,23H,4-5,7,9-12,16H2,1-3H3,(H2,29,30)(H,31,35)/t17-,23+/m0/s1 |
| InChIKey | DHAGMIPSRSPWSH-GAJHUEQPSA-N |
| SMILES | CCC1=C(N=CC(=C1)NC(=O)C(=O)N2CC(CCC2C3=CC4=C(C=C3)SC(=N4)C5CCN(CC5)C)C)N |
| Reference | [1]. Kevin M Cottrell, et al. Piperidin-1- yl-n-pyrydi ne-3-yl-2-oxoacet am ide derivatives useful for the treatment of mtap-deficient and/or mt a-accumulating cancers. Patent WO2022026892A1. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
