TNG260

For research use only. Not for therapeutic Use.

  • Cancer Immunotherapy
  • CAT Number: I041366
  • CAS Number: 2935964-98-8
  • Molecular Formula: C20H18FN3O2S
  • Molecular Weight: 383.44
  • Purity: ≥95%
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TNG260 is a CoREST-selective deacetylase (CoreDAC) inhibitor. TNG260 inhibits HDAC1 with 10-fold selectivity over HDAC3. TNG260 leads to HDAC1 inhibition, reverses anti-PD1 resistance driven by loss of STK11. TNG260 decreases intratumoral infiltration of neutrophils. TNG260 exhibits immune-mediated cell killing[1].


Catalog Number I041366
CAS Number 2935964-98-8
Synonyms

N-[2-amino-5-(4-fluorophenyl)phenyl]-4-(methylsulfonimidoyl)benzamide

Molecular Formula C20H18FN3O2S
Purity ≥95%
InChI InChI=1S/C20H18FN3O2S/c1-27(23,26)17-9-4-14(5-10-17)20(25)24-19-12-15(6-11-18(19)22)13-2-7-16(21)8-3-13/h2-12,23H,22H2,1H3,(H,24,25)/t27-/m1/s1
InChIKey JPFMYSJUFUEHBI-HHHXNRCGSA-N
SMILES CS(=N)(=O)C1=CC=C(C=C1)C(=O)NC2=C(C=CC(=C2)C3=CC=C(C=C3)F)N
Reference

[1]. Ahronian L, et al. TNG260, a CoREST-selective deacetylase inhibitor, reverses anti-PD1 resistance driven by loss of STK11[J]. J Immunother, 2022, 10(2): A1-A1595.

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