TNIK-IN-1

• CAT Number: I037373
• CAS Number: 933886-36-3
• Molecular Formula: C19H17N5O3S
• Molecular Weight: 395.43
• Purity: ≥95%
• Synonyms: 5-[(4-acetamidobenzoyl)amino]-2-anilino-1,3-thiazole-4-carboxamide
• InChI: InChI=1S/C19H17N5O3S/c1-11(25)21-14-9-7-12(8-10-14)17(27)24-18-15(16(20)26)23-19(28-18)22-13-5-3-2-4-6-13/h2-10H,1H3,(H2,20,26)(H,21,25)(H,22,23)(H,24,27)
• InChIKey: OOYMGIRITPQNDA-UHFFFAOYSA-N
• SMILES: CC(=O)NC1=CC=C(C=C1)C(=O)NC2=C(N=C(S2)NC3=CC=CC=C3)C(=O)N

TNIK-IN-1 (Compound 1) is an inhibitor of Traf2 and Nck-interacting kinase (TNIK), with IC50 of 65 nM, that has antitumor activity[1].

Reference

[1]. Koc-Kan Ho, et al. Discovery of 4-phenyl-2-phenylaminopyridine based TNIK inhibitors. Bioorg Med Chem Lett. 2013 Jan 15;23(2):569-73.
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